In vitro antimicrobial susceptibility of bovine farcy organisms

Abstract

The in vitro activities of 35 various antimicrobial agents were tested against 42 Mycobacterium farcinogenes, 13 M. senegalense, 17 Nocardia farcinica strains using glucose yeast extract agar medium. Most of the M. farcinogenes strains were susceptible to amikacin (2 µg/ml), doxycycline HCl (8 µg/ml), erythromycin (64 µg/ml), lividomycin sulfate (16 µg/ml), minocycline HCl (8 µg/ml), nalidixic acid (64 µg/ml), oleandomycin phosphate (64 µg/ml), oxytetracycline HCl (64 µg/ml), rifampicin (64 µg/ml), streptomycin sulfate (64 µg/ml) and vancomycin (64 µg/ml). A distinct resistance profile to the antituberculous drugs was noted for most of the test strains, though M. senegalense and N. farcinica showed much more resistance than M. farcinogenes. The pattern of drug susceptibility to antimicrobial agents proved useful in differentiating between M. farcinogenes and M. senegalense and between these two and N. farcinica. It may have significant therapeutic implications in bovine farcy.