Comparative activity of anthelminthic drugs, mebendazole, praziquantel and albendazole against Hymenolepis diminuta in experimentally infected rats

Abstract

Experimentally Hymenolepis dimhuta infected rats were treated orally with sinale and eaual divided doses of the three anthelmintic drugs >30 days after infection. Praziquantel (250 mgkg and 83 me/ke/dav for 3 consecutive days) and albendarole (800 mg/kg and 267 mg/kg/day for 3 consecutive days) completely eliminated the worms, while mebendazole (500 mg& and 167 mg/kg/day for 3
consecutive days) partially eliminated the worms with an efficacy of 76 p. 100. Among the three anthehnintic drugs, there was no significant difference in efficacy between treatment with single and divided doses. No toxicity developed in treated rats.