Kinetic and therapeutic properties of macrocyclic lactone endectocides, doramectin and moxidectin, in N’Dama cattle (Bos taurus) in Gabon

Abstract

The plasma kinetics and efficacy of doramectin and moxidectin were studied in N’Dama taurine cattle after subcutaneous administration at the recommended dose of 0.2 mg/kg. Absorption half-life values showed that the absorption of moxidectin (0.05 day) was significantly faster than that of doramectin (1.7 day). No significant differences were observed in maximum concentrations, but they were reached earlier with moxidectin (0.3 day) than with doramectin (4.8 days). Exposure, measured by the area under the curve, was higher for doramectin (458 ng.day/ml) than for moxidectin (159 ng.day/ml), whereas moxidectin seemed more remanent. Both molecules showed 100% efficacy between days 15 and 30 posttreatment. These results are similar to those observed in other taurine breeds. Doramectin and moxidectin can therefore be recommended to control gastrointestinal parasitoses in N’Dama in humid tropical regions.